76 pages • 2 hours read
Patrick Radden KeefeA modern alternative to SparkNotes and CliffsNotes, SuperSummary offers high-quality Study Guides with detailed chapter summaries and analysis of major themes, characters, and more.
In many respects, Empire of Pain is a story of what happens when personal ambition intersects with social and medical history. The American dream prizes personal ambition—an ideal that the Sacklers seemed poised to live up to. Isaac and Sophie Sackler were among the many immigrants driven to the United States; Sophie’s hopes that her sons would become doctors were common: “there was a sense that doctors were morally upright, and it was a vocation that served the public good” (17). Growing up, Arthur Sackler’s high school for talented students was full of fellow immigrants determined to succeed in life. Arthur decided early on that his talents belonged in business as well as medicine. He would be proven correct, since his talent for medical advertising launched a new industry.
But ambition divorced from ethics is a recipe for corruption, greed, and other problems. Where both Isaac and Arthur Sackler had a strong sense that moral worth was a key part of an individual’s merits, successive generations of the Sackler family were more concerned with maintaining status. For example, though Richard Sackler “admired his uncle Arthur” (147), he was more concerned with establishing himself as a generator of wealth. When Purdue launched its first opioid painkiller, MS Contin, employees were told that its sales were “for Richard” (161). The company was identified so closely with Richard that it became a personality cult, requiring public displays of loyalty. Purdue executives frequently had to rein in Richard’s goals, including his original idea to market OxyContin over the counter in parts of Europe.
While Richard’s ambition remained focused on OxyContin’s sales, company profits, the culture of secrecy about the family’s source of income drove the decisions of future generations of Sacklers, whose primary ambition was to maintain their luxury lifestyles. This narrow-minded greed prompted them to move money offshore to avoid tax obligations, all while striving to establish themselves in fields far from Purdue. The examples of Joss and Madeleine Sackler show the tone-deafness and self-delusion of the third generation—each wanted cultural and artistic credibility without ever accounting for their family’s effect on the country.
Conversely, the narrative’s non-Sackler characters tend to combine ambition with a sense of honor. Nan Goldin, for example, felt that it was her moral duty as an artist to oppose the Sackler influence over art institutions. Massachusetts Attorney General Maura Healey insisted that much of the family’s wrongdoing be made public to ensure that their public image matched reality. In the end, the family’s adversaries won the contest for reputation, making sure that the Sacklers would not be able to continue their obfuscation.
Arthur Sackler created a family culture of secrecy, obscuring business ties and tactics—a culture that lasted for generations. Secrecy led inevitably to corruption; cutting ethical corners became a way to earn profit and avoid accountability. Early in his career, Arthur became a “silent partner” in his rival’s ad agency (49-50) and also hid his ownership of a medical newspaper that ran his agency’s ads, maximizing his client list and personal wealth while ignoring the obvious conflicts of interest. This led to other ethical lapses: Arthur’s advertising clients had close ties with the FDA, effectively neutering its regulatory control powers. Arthur’s brother Raymond and his nephew Richard later used similarly close relationships with the FDA to launch products more quickly and with less oversight: Raymond sold MS Contin before full FDA approval without repercussions, and Richard participated in creating the “package insert” for OxyContin (194-95), which made false claims about the drug’s harmlessness and duration.
The Sacklers also used secrecy to advance their personal brand as socially conscious philanthropists, loath to be fully open about their ties to Purdue. Arthur Sackler rarely publicly claimed his role in the launch of Valium, and Mortimer Sackler’s obituary “made no mention of OxyContin” (304), focusing instead on his artistic and educational giving. Madeleine Sackler made similar efforts to deny any relationship between Purdue’s role in the drug use disorder epidemic and the prisons she made documentary films about. Radden Keefe’s 2017 New Yorker profile of the family was among the first to connect the Sacklers explicitly with OxyContin and Purdue, showing just how long this habit of secrecy endured.
From the early partnership of Arthur, Raymond, and Mortimer Sackler to later generations, the Sacklers displayed a notable tendency to be a united front advocating for the family’s prosperity and survival. In early years, this sense of family loyalty was protective and part of a commitment to public service. Arthur, Raymond, and Mortimer entered into a “musketeer’s agreement” with Bill Frolich so that they would be stewards of each other’s wealth and charitable goals, so that they would not “hoard” their good fortune (51). The original purchase of Purdue was meant to help Raymond and Mortimer maintain stable careers after the Red Scare forced them out of psychiatric practice at Creedmoor.
However, this cohesion was undimmed even when it meant engaging in legally or morally suspect behavior, taking on a more complex note as Radden Keefe’s narrative turns to Richard and Kathe Sackler and their children, nieces, and nephews. Family politics often closely intersected with agency and electoral politics: Just as Arthur Sackler depended on close relationships with the FDA to cut corners, so his nephew Richard took care to reward Curtis Wright, the former official who fast-tracked the approval of OxyContin. The family lavishly rewarded personal loyalty—for instance, paying Howard Udell and his co-defendants for not testifying against the family on the witness stand.
The later generation felt that their wealth should transcend conventional civic obligations. The Sacklers wanted to be known as philanthropists, but that “the gifts be on their own terms—to the arts and sciences, with naming rights—rather than be left to the discretion of the state” (328). They avoided taxes and sought to shelter their fortune, all the while actively courting political patrons, like ex-Mayor Michael Bloomberg, and threatening unfriendly politicians with the withholding of campaign contributions, as in the case of attorney general Richard Blumenthal. Radden Keefe strongly implies that both the Bush and Trump Justice Departments gave in to pressure to shield the family from the more serious consequences of the legal actions against them.
Testifying to Congress in 2021, David Sackler felt his family’s diminished influence after decades of public scrutiny. David encountered the open contempt of members of Congress—voices of “collective indignation” (432). Though the family successfully utilized bankruptcy court to minimize its liability, and the Department of Justice was convinced not to pursue charges, Radden Keefe argues that the dynasty’s political power is now on the wane—a good thing.
In private life, the Sacklers avoided unpleasant truths. Arthur Sackler, for example, ignored that his relationship with Marietta Lutze might not be compatible with remaining married to his first wife, until Marietta “was pregnant [and] forced a decision” (33). Decades later, Arthur refused Marietta’s requests for a divorce, planning to carry on his newest relationship while remaining married. None of the family ever mentioned Bobby Sackler after his death via drug overdose, until Kathe spoke about him briefly in 2021.
This personal preference for denial spilled over into Purdue’s corporate governance and handling of any legal or moral responsibility for the opioid use disorder epidemic. Arthur discounted the prevalence of Valium overdoses, insisting people “must have mixed it with alcohol or cocaine” (65). Later, though not all members of the family got along, they all shared in a “collective denial” of culpability for the opioid crisis: After the 2008 guilty plea in federal court, when some “revisionist voices” counseled new tactics, including a statement to show a “modicum of compassion” for those who had suffered (342-43), the family refused.
However, a long line of attorneys and journalists have tried to force accountability. Among the first was Barry Meier of the New York Times, whose investigative journalism was so effective that the Sacklers did their best to undermine his credibility. Nan Goldin’s activism, featuring art-installation protests like the pill bottle in the Sackler Wing of the Met reading, “OxyContin, prescribed for you by the Sacklers” (362), was another tangible effort to insure that the family became associated with Purdue Pharma. Maura Healey insisted on a full legal reckoning for Purdue and the Sackler family, though the results were less far-reaching than she might have hoped. Radden Keefe also faces the family’s stonewalling, as the Sacklers and their attorney, Tom Clare, insist that his journalism is fundamentally flawed and should not be published. In a way, Empire of Pain functions as a witness to other witnesses, as Radden Keefe foregrounds those who were concerned about the Sackler family’s tactics, from Senator Kefauver to present-day actors like New York Attorney General Leticia James.
American medicine relies both on empirical science and also on marketing and sales. Arthur Sackler and his brothers began their professional careers in a time when the science of antibiotics revealed the power of pharmaceutical treatments to fight previously fatal disease. This inspired Arthur’s own research into medical and less invasive treatments for mental illness. However, the lucrative business of antibiotics also bolstered Arthur’s decision to go into medical advertising, which relied on spin as much as empirical fact. While declaring that medical advertising had a noble, pedagogical purpose, Arthur published sensationalized stories about tranquilizers calming captive wildcats to sidestep laws against direct advertising of medicines to consumers.
Many of Purdue’s later decisions about OxyContin were shaped not only by scientific advances, but also by intellectual property demands. Since drug patent exclusivity had strict time limits, after which profits would fall off because generic cheaper alternatives could be produced by competitors, Richard Sackler and his generation often made business decisions with patent exclusivity in mind. For instance, the production of tamper-proof OxyContin, which could not be crushed to achieve a faster high, was not driven entirely by moral or public health concerns. The new formulation also extended Purdue’s patent exclusivity.
Eventually, science stopped factoring in Purdue’s decisions altogether. Rather than investing in the research and development of new drugs, “there was no way the Sacklers were going to get out of the opioid trade. It was simply too profitable” (293). Even when Mortimer Sackler expressed concern that the family’s focus on painkillers was a liability after the 2008 federal case, the family continued to focus on OxyContin sales. One of Radden Keefe’s sources even posits that the 2019 bankruptcy was merely a recognition that the patent exclusivity could no longer be extended.
Though multiple generations of the Sackler family professed a belief in the nobility of medicine and the importance of helping patients, much of the family’s story reveals that 20th- and 21st-century medicine was primarily a business, yielding enormous wealth for those in a position to use science to create medical advancements and then use legal tools to protect their gains. Innovation is clearly good—pain patients do derive benefits from pain management. The problem emerges when these public benefits serve more as a rhetorical cover for business greed.
By Patrick Radden Keefe
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